This book is a description of these natural chemicals: how they are synthesized and metabolized, how they act at both the organismal and molecular levels, how we measure them, a description of some of the roles they play in regulating plant growth and development, and the prospects for the genetic engineering of hormone levels or responses in crop plants. This is an updated revision of the third edition of the highly acclaimed text. Thirty-three chapters, including two totally new chapters plus four chapter updates, written by a group of fifty-five international experts, provide the latest information on Plant Hormones, particularly with reference to such new topics as signal transduction, brassinosteroids, responses to disease, and expansins. The book is not a conference proceedings but a selected collection of carefully integrated and illustrated reviews describing our knowledge of plant hormones and the experimental work that is the foundation of this information.
Failure of MC2R to activate in response to ACTH causes familial glucocorticoid deficiency (FGD), a rare autosomal recessive disorder characterized by severe cortisol deficiency with high plasma ACTH concentrations and normal mineralocorticoid levels. MC2R mutations resulting in effective loss of the receptor function are responsible for FGD type 1, which accounts for up to 25 percent of all FGD cases [ 5 ]. (See "Causes and clinical manifestations of primary adrenal insufficiency in children", section on 'Familial glucocorticoid deficiency (FGD)' .)