If too much corticosteroid cream becomes absorbed through the skin, serious complications can result, including adrenal gland suppression and Cushing's syndrome. In adrenal gland suppression, the body stops manufacturing its own steroids, so the patient may become dependent on the drug. Cushing's syndrome causes symptoms including diabetes, high blood pressure, and muscle weakness. Local side effects are also possible due to misuse of corticosteroid cream. These can include skin atrophy, stretch marks , susceptibility to infection, allergy , easily bruised or injured skin, and enlarged blood vessels.
Most clinicians in private practice are regularly faced with challenging dermatologic cases, and a common question arises: How much prednisone is too much? No one can definitively answer this question, as different dogs respond in different ways. Some patients are unaffected by long-term prednisone administration, while others immediately demonstrate polyphagia, polydipsia and polyuria, or incontinence. Still others show signs of iatrogenic Cushing's disease—muscle wasting, a pot-bellied appearance, and muscle weakness—early on in therapy. The best approach is to try the safest treatment first, monitor the patient's response carefully, and adjust the therapeutic protocol if side effects become problematic or the condition does not respond.