NSAIDS have antipyretic activity and can be used to treat fever.   Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation.   Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus .   PGE2 signals to the hypothalamus to increase the body's thermal set point.   Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen).   Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.
What singles out Rob Anthony from a musical standpoint is his ability to write relatable lyrics within the musical structure of great acoustic guitar. A local singer-songwriter who believes in giving back to the community, he writes from the heart. His music transcends the typical fun and games to really hit home on many issues ranging from the personal to the national. And those lyrics have given him opportunities to connect with people across the nation. The song “Down the Road” is one of many compositions in his collection that has touched the lives of a specific group and in turn gives them a bond on a musical level. Anthony’s songs however, reach out to everyone. > Read More