Q. Had FMS for almost twenty years now, tried almost everything. Is Lyrica in the "steroid" family? Any one in this community could help me? I have given my few questions to find out an answer. I Had FMS for almost twenty years now, tried almost everything. I'm considering Lyrica but I'd like more info. Is Lyrica in the "steroid" family? If you go on Lyrica for a while & see no improvement with pain, is going off of it a big deal like with other med's, or can you simply just stop taking it? I take Ambien, will that have any interactions? I'm seeing my Doc about this at the end of the month, but I was hoping to get some personal experiences about it. Thanks for any thoughts! Thanks for your answers, keep them coming! A. according to this-
there is a moderate interaction. that means you can take them both but be checked regularly for depression of breath.
Fetal Leydig cells produce testosterone in high amounts. There is circumstantial evidence that placental production of chorionic gonadotropin (hCG), which peaks at 12 weeks of fetal age, controls early fetal gonadal steroidogenesis (6). Testicular capacity of hCG binding is maximal at 15-20 weeks (32). Studies of the steroidogenic enzymes and of the expression of the steroidogenic enzyme genes have shown that cholesterol side-chain cleavage enzyme (P-450scc), adrenodoxin (iron-sulfur protein serving as an electron transport intermediate for P-450scc) and P-450c17 (17a-hydroxylase/17,20-lyase) genes are highly expressed in the fetal testis, mainly during the 14 th and the 16 th weeks. After 16 weeks, P-450c17 mRNA decreases more rapidly than P-450scc mRNA does (57). This age related pattern of P-450scc and P-450c17 mRNA is similar to fetal testicular and serum testosterone concentrations (44,45,52), and relates to the variations in hCG production and hCG receptors. These findings suggest that the expression of the steroidogenic genes is directly regulated by circulating hCG. The P-450Arom (aromatase gene) is poorly expressed in the fetal testis. The lack of significant local estradiol production may be an explanation for the non-desensitization of the fetal Leydig cells in the presence of high levels of hCG (29).