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Muscimol is a potent GABA A agonist , activating the receptor for the brain's principal inhibitory neurotransmitter , GABA . Muscimol binds to the same site on the GABA A receptor complex as GABA itself, as opposed to other GABAergic drugs such as barbiturates and benzodiazepines which bind to separate regulatory sites.  GABA A receptors are widely distributed in the brain, and so when muscimol is administered, it alters neuronal activity in multiple regions including the cerebral cortex , hippocampus , and cerebellum .