(Level III) Following initial stabilization of patients with severe sepsis, maintain blood glucose from 80 – 110 mg/dL with continuous infusion of insulin and glucose. With this protocol, glucose should be monitored frequently after initiation of the protocol (every 30 – 60 mins) and on a regular basis (every 4 hrs) once the blood glucose concentration has stabilized. [NEJM 345: 1359, 2001] (Level IV or V) In patients with severe sepsis, a strategy of glycemic control should include a nutrition protocol with the preferential use of the enteral route.
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