As for bodybuilders, Stanozolol has one interesting peculiarity demanded among them. It consists in the profound ability to lower sex hormone-binding globulin (SHBG) level resulting in efficiency growing of other steroids in stack with it. In particular, it raises the amount of biologically active free testosterone circulating in the blood. For this reason it is advisable always to use Stanozolol in stack with testosterone. Another one reason for this is as follows: Winstrol may be more prone than other anabolic steroids to increasing tendon brittleness. This happens due to Winstrol`s possibility to dry out the joint fluid, which can lead to joint pain and damages. Also both Stanozolol forms: tablets and injections have been noted to provoke adverse changes in cholesterol levels. Hence, monitoring of the lipid profile of the body (blood works) during cycle is advisable.
Metabolic effects occurring during anabolic steroid therapy in immobilized patients or those with metastatic breast disease include osteolytic-induced hypercalcemia.
Anabolic steroids effect electrolyte balance, nitrogen retention, and urinary calcium excretion. Edema, with and without congestive heart failure, has occurred during anabolic steroid therapy.
The androgenic activity of anabolic steroids may decrease levels of thyroxin-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.
Significant increases in low density lipoproteins (LDL) and decreases in high density lipoproteins (HDL) have occurred. [ Ref ]